https://www.selleckchem.com/pr....oducts/idasanutlin-r
AMPAR transmission in NAc medium spiny neurons was assessed with exvivo slice recordings. mGlu stimulation reduced cue-induced craving and removed synaptic CP-AMPARs. When the ISR was blocked prior to mGlu stimulation, there was no reduction in cue-induced craving, nor were CP-AMPARs removed from the synapse. Further, selective knockdown of oligophrenin-1 blocked mGlu -LTD. Our results indicate that mGlu -LTD in the NAc and consequently the reduction of cue-induced seeking occur through activation of the ISR, which induces t
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