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This method is practical because it uses readily available reagents and equipment and is sensitive enough for the rapid screening of cyanide poisoning in forensic and clinical toxicology.Paints are a common form of physical evidence encountered at crime scenes. This research presents an optimized method for the untargeted analysis of volatile organic compounds (VOCs) in spray paint using solid-phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS). The presence and persistence of VOCs were monitored in 30 minute intervals