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The importance of drug dosing time in pharmacokinetics, pharmacodynamics and toxicity is receiving increasing attention from the scientific community. In spite of mounting evidence that circadian oscillations affect drug absorption, distribution, metabolism and excretion (ADME), there are yet many unanswered questions in this field and occasionally conflicting experimental results. Such data arise not only from translational difficulties caused by interspecies differences, but also from variability in study design and a lack of underst