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In Thailand, the palm oil industry produces a huge amount of palm oil mill effluent (POME), mostly used for electricity generation through biogas production. Co-digestion with other waste can further improve biogas yield and solve waste management problems. Most previous studies relied on biochemical methane potential (BMP) assay or batch co-digestion to obtain the optimal mixing ratio, ignoring the kinetic part or treat it for sole discussion of the results. This work directly uses mechanistic models based on Monod kinetics to describe