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We observed a very weak association of Lp(a) levels with UDPRS III scores. In cross-sectional analyses, no other lipid fraction revealed a significant and consistent association with motor or cognitive function. During follow-up, no lipid fraction level was associated with motor or cognitive progression. In advanced PD, there is no strong and consistent association of lipid levels with motor or cognitive function and decline. In advanced PD, there is no strong and consistent association of lipid levels with motor or cognitive function and