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Polyporus polysaccharide (PPS), obtained from Chinese herbs, has resistant regulation, anticancer, antioxidant and antiinflammatory tasks. This study aims to research antifibrotic outcomes of PPS. We show that PPS markedly ameliorates bleomycin-induced lung fibrosis in mice. Myofibroblasts will be the effector cells accountable for exorbitant deposition of extracellular matrix (ECM) proteins in fibrotic diseases. In vitro proof shows that PPS exe