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Thus, we can conclude that TBT has different toxicological effects on male and female rats by altering thyroid gland morphophysiology, leading to abnormal HPT axis function, and even at subacute and low doses, it may be involved in complex endocrine and metabolic disorders.Bisphenol A (BPA) is a synthetic organic compound that is mainly used in the production of polymer materials polycarbonate and epoxy resin. Widespread use and irregular processing methods have led to BPA being detected globally, raising concerns about its environmental