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In this study, 63 groundwater samples were collected in the Kashgar Delta Area in Xinjiang in 2016, and then, the samples were tested and the test results were analyzed. Multivariate statistical techniques were used to determine the sources of pollution, and the USEPA (United States Environmental Protection Agency) model was used to assess the long-term health risk of groundwater to adults and children in the study area. The concentrations of groundwater chemical Na+, Cl-, SO42-, NH4+-N, TDS, F-, I-, As, Fe, Mn, Pb, Hg, pH, TH, and CODMn