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QRDRs in gyrA identified amino acid codon mutations Ser83Leu and Asp87Asn and, Ser80Ile in parC. Docking analysis implied that marbofloxacin could not form strong complexes with mutated DNA-gyrase. A high prevalnce of PMQR genes, especially qnrS, was observed along with overexpression of AcrAB-TolC efflux pump. CONCLUSIONS The study highlighted high prevalence of transferable mechanisms of quinolone resistance and over-expression of efflux pumps in marbofloxacin-resistantE. coli isolates apart from classic QRDR mutations. The present s
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