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The slope of estimated glomerular filtration rate change was-1.46 (-1.66 to-1.26) mL/min/1.73m per year for the overall group, with no significant differences between ADAS genes (P=0.2). The relatively small size of this series from a single country, potentially limiting generalizability. Patients with ADAS have a wide spectrum of clinical presentations, ranging from asymptomatic to kidney failure, a pattern not clearly related to the causative gene or type of variant. The diversity of ADAS phenotypes contributes to its underdiagnosis i