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The pharmacokinetics (PKs) of cisplatin have not been investigated in patients with renal dysfunction, characterized by creatinine clearance (Ccr) 60mL/min. In this study, we performed a population pharmacokinetic (PPK) analysis of unchanged cisplatin in patients with renal dysfunction. We investigated the effects of renal dysfunction on the PKs and nephrotoxicity of unchanged cisplatin. We enrolled 23 patients with moderate renal dysfunction (Ccr calculated to be 30-60mL/min using the Cockcroft-Gault formula) treated with cisplati
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