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It is very rare that metastatic melanomas and even more primary melanoma tend to be negative for many of those markers. During these infrequent cases, discover usually a known primary. We present the actual situation of a 82-year-old woman with a erythematous size in the remaining crotch and a 1-cm black-bluish irregular nodule in the skin regarding the ipsilateral foot. This lesion was medical and dermoscopically appropriate for main melanoma. Within the histological evaluation of the skin, a