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Interactions with biological obstacles were examined in vitro by identifying cell viability, particle uptake, oxidative stress reaction and DNA problems following AgNP therapy. Outcomes revealed a difference in cytotoxicity according to the surface layer useful for AgNP stabilization. All three types of AgNP caused apoptosis, oxidative stress response and DNA harms in cells, but AOT- and PVP-coated AgNP exhibited lower toxicity than definitely charged PLL-AgNP. Considering the wide range
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