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The results obtained in this work proclaimed that the combination of such correlative microscopy with our NI-SP probe is an effective modality for ultrastructural analysis and has future applications in various complex systems such as tissue/organ imaging.A peculiar clock-regulated design of FeMn-LDHs (FMH) with specific physiochemical attributes has been developed and used for highly sensitive detection of cysteine (CySH) and dopamine (DA). The FMH nanoparticles were synthesized via a facile hydrothermal approach clocked at various (6 h