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BACKGROUND Statins are used as cholesterol-lowering drugs and may also have direct antimicrobial effects. OBJECTIVE To evaluate synergic interactions between simvastatin and both amphotericin B and fluconazole, against environmental strains of Cryptococcus neoformans isolated from captive birds' droppings. DESIGNAND SETTING Experimental study conducted at Federal University of Piauí, Parnaíba, in collaboration with Federal University of Triângulo Mineiro, Uberaba, Brazil. METHODS Statin susceptibility tests of Cryptococcus neoformans sa
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