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2 years; nonfrequent users 53.4 years; p less then 0.01) and required immediate and mental health care more frequently (18.6% of high-frequency users, 17.4% of frequent users, 13.5% of nonfrequent users, and 6.6%; 3.3%, 2.3%; p less then 0.01). High-frequency users also used the ED for nonurgent reasons more than remaining groups (6.1%, 3.5%, 3.1%; p less then 0.01). CONCLUSION High-frequency users are an aged and heterogeneous group, requiring tailored interventions to improve care. PURPOSE Ceftazidime/avibactam (CAZ-AVI) is a fixed-dos