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Our initial X-ray fluorescence test on granules from local Langerhans islets and insulinoma-derived INS-1E cells uncovered a considerable difference in the zinc content. This led our additional research to judge the impact of the intra-granular Zn2+ levels on the production and storage space of insulin in different design β-cells. Right here, we systematically compared zinc and insulin items when you look at the permanent INS-1E and BRIN-BD11 β-cells and in the native rat pancreatic islets by circ