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he effect of WNT1 c.110 TC and c.505GT missense mutations on osteoblast differentiation and propose a new molecular mechanism for OI development. T missense mutations on osteoblast differentiation and propose a new molecular mechanism for OI development. Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimination are still not fully understood for this class of antibodies. The o