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Stimulant Vs Non Stimulant ADHD Medication The most frequently prescribed medication prescribed by healthcare professionals to treat ADHD is stimulants. They target specific brain chemicals, like dopamine and norepinephrine, in order to enhance symptoms of impulsivity and inattention. Nonstimulant medicines are second-line treatments for people who do not respond to stimulants. They also have fewer adverse effects. They target various neurotransmitters or receptors Stimulant medications are