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Cold EMR is being increasingly used for large serrated lesions. We sought to measure residual lesion rates and adverse events after cold EMR of large serrated lesions. In a single academic center, we retrospectively examined a database of serrated class lesions≥10mm removed with cold EMR for safety and efficacy. Five hundred sixty-six serrated lesions≥10mm in size were removed from 312 patients. We successfully contacted 223 patients (71.5%) with no reported serious adverse events that required hospitalization, repeat endoscopy, or transf