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This 'crosstalk' does occur in both the steady state and after a variety of insults, as an example, in response to regional injury, at web sites of disease or disease. What do we suggest by crosstalk between cells? Reciprocal activation and/or regulation happens between resistant and stromal cells, by direct cellular contact and indirect systems, including the release of soluble cytokines. Moving beyond cell-to-cell contact, this analysis investigates the complexity of 'cross-space' mobile communica