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The fabrication process is not difficult and mild without involving high temperatures or irradiation, and may be used to an easy spectrum of popular polymers (age.g., cellulose acetate (CA), polysulfone (PSF), polyethersulfone (PES), polylactic acid (PLA), etc.). Due to the capillary effect and large cavity distributed by very permeable and interconnected structures, the ensuing permeable polymer MNs reveal the capability of quickly removing dermal interstitial substance (ISF) and effortle