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As co-stimulatory receptors play key functions in controlling the effector features of T cells, activating co-stimulatory paths may enhance checkpoint inhibition efficacy, and result in durable antitumor reactions. Here, we review current advances inside our understating of co-stimulatory receptors in cancers, providing the required groundwork for the rational design of disease immunotherapy. Acute viral illness or vaccination makes very useful memory CD8 T cells following Ag quality. In contrast, persiste
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