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Further analysis showed patients in high-risk group possess more complex TME and immune cell composition. Taken together, our research suggests the thirteen-gene signature to possess potential prognostic value for HCC patients and provide new information for immunological research and treatment in HCC. Taken together, our research suggests the thirteen-gene signature to possess potential prognostic value for HCC patients and provide new information for immunological research and treatment in HCC. Habitual smoking of tobacco and marijuan