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Our preliminary result identified six significant SNPs located in six different genes. All of them and their genetic products may warrant further investigations. Previous studies have reported the efficacy of human mesenchymal stem cell (MSC) exosomes for the repair of osteochondral defects in rats and rabbits. However, the safety and efficacy of MSC exosomes remain to be validated in a clinically relevant large animal model. To validate the safety and efficacy of human MSC exosomes for osteochondral repair in a clinically relevant micr