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The DIPSG bias was-5 (-25; 15) for AHI and-3 (-13; 7) for minimal oxygen saturation. N2 sleep was increased (32.9% vs. 50.75%, respectively; p0.01) and REM sleep was decreased (21.35% vs. 1.24%, respectively; p0.01) during DIPSG. Twenty-eight (33%) participants had postural shifts during DIPSG. No significant adverse events were observed during DIPSG. Dexmedetomidine-induced PSG had a good sensitivity and specificity, and can be used as a screening tool for diagnosis of OSA in adults. ChiCTR1900024044. ChiCTR1900024044. Adolesce