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IGF-1 treatment inhibited mitochondrial apoptosis in a dose-dependent manner in the LPS-treated cells. The reagent also increased the expression of p-GSK3β and decreased the expression of NF-κB and NLRP3. Both LY294002 and betulinic acid reversed the protective effect of IGF-1. In addition, LY294002 affected the expression of the three signaling proteins, while betulinic acid only affected the expression of NF-κB and NLRP3. These findings indicated a GSK3β/NF-κB/NLRP3 signaling pathway was existed and was involved in the protective

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rchers was positive about the potential for IMUs to contribute accurate data about active range of motion, especially in children, for whom goniometric methods are challenging. There may also be potential to use IMUs for continued monitoring of hand movements throughout the day. Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12614001276640, https//www.anzctr.org.au/Trial/Regist....ration/TrialReview.a ANZCTR ACTRN12614001275651, https//www.anzctr.org.au/Trial/Regist....ration/TrialReview.a Australian N