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elay (odds ratio 3·15, 95% CI 1·16-8·84). INTERPRETATION In critically ill adults with HIV-tuberculosis, M tuberculosis BSI is a frequent manifestation of tuberculosis and predicts mortality within 30 days. Improved diagnostic yield in patients with M tuberculosis BSI could be achieved through combined use of sputum Xpert and urine LAM. Anti-tuberculosis treatment delay might increase the risk of mortality in these patients. FUNDING This study was supported by Wellcome fellowships 109105Z/15/A and 105165/Z/14/A. Previously, we demonstrat
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