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In order to elucidate some unique insights of Lycium barbarum (Goji berry) activity on epidermis cells, the current research focused on its energetic mixture zeaxanthin. By focusing on the stemness markers CD44 and CD105, with deep implications in epidermis oxidative anxiety mechanisms, we unveiled, for the first time, selectivity in zeaxanthin task. When applied in vitro on BJ human fibroblast cell line versus the A375 cancerous melanoma cells, despite the modest cytotoxicity, the zeaxanthin-