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Adolescents with beta thalassemia major face various physical and psychosocial challenges. Resilience plays a protective role in coping with the stress resulting from this disease. This descriptive correlational study was carried out on 134 adolescents (age 11-21 years old) with beta-thalassemia major who were referred at the Thalassemia Centre in southern Iran from October to December 2018 via convenience sampling method. The Jalowiec Coping scale and Connor-Davidson resilience scale were the instruments used in this study. Data analys