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To examine the association between antenatal and postnatal maternal depression symptoms, and child hospitalization during the first 2years of life in the 2015 Pelotas Birth Cohort Study. This is an observational study. Maternal depressive symptoms of 4275 mothers were measured using the Edinburgh Postnatal Depression Scale. Hospitalization of the child for any reason was assessed using maternal report. Bivariate analysis and multivariate Poisson regressions were used to assess the association between maternal depressive symptoms and chi