https://www.selleckchem.com/pr....oducts/ly2606368.htm
These changes were mediated by a shift to non-amyloidogenic cleavage of the human amyloid precursor protein (APP), recovery of the neurovascular unit and maintaining microglial metabolic fitness. Mechanistically, Klk8-knockdown improved Aβ phagocytosis in primary glia and Aβ resistance in primary neurons. Most importantly, transgenic mice revealed less anxiety and a better memory performance. These results reinforce the potential of KLK8 as a therapeutic target in AD. These results reinforce the potential of KLK8 as a therapeutic targ
Like
Comment
Share
