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Adhesive bonding are becoming increasingly important in civil and mechanical engineering, in the field of mobile applications such as aircraft or automotive. Adhesive joints offer many advantages such as low weight, uniform stress distribution, vibration damping properties or the possibility of joining different materials. The paper presents the results of numerical modeling and the use of neural networks in the analysis of dual adhesive single-lap joints subjected to a uniaxial tensile test. The dual adhesive joint was created through the use of

https://www.selleckchem.com/
Osteosarcoma (OSA) is a heterogeneous and aggressive solid tumor of the bone. We recently identified the colony stimulating factor 1 receptor (Csf1r) gene as a novel driver of osteosarcomagenesis in mice using the Sleeping Beauty (S transposon mutagenesis system. Here, we report that a CSF1R-CSF1 autocrine/paracrine signaling mechanism is constitutively activated in a subset of human OSA cases and is critical for promoting tumor growth and contributes to metastasis. We examined CSF1R and CSF1 expression in OSAs. We utilized gain-of-function and loss-of-fu