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The purpose of the present research was to explore the part of lncRNA Gas5 in the hypoxia-stimulated expansion and migration of human being PASMCs (hPASMCs). We discovered that the phrase of Gas5 ended up being down-regulated in a rat model with hypoxia plus in cultured hypoxic hPASMCs, and silence of Gas5 notably promoted hPASMCs proliferation and migration both in regular and hypoxia problem. Subsequent researches disclosed that miR-23b-3p interacted with Gas5