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Our results suggest that genomic architecture and gene regulation may be influenced by cellular morphology and movement during development. Circular RNA (circRNA) plays an important role in the malignant progression of many tumors, including retinoblastoma (R. However, the role and regulatory mechanism of circ-E2F3 in RB have not been fully elucidated. Quantitative real-time PCR was used to measure circ-E2F3, miR-204-5p and Rho-associated protein kinase 1 (ROCK1) expression. Cell proliferation, apoptosis and metastasis were monitored
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