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Purpose To mine differentially expressed microRNAs (miRs) in lung adenocarcinoma (LUAD) via The Cancer Genome Atlas (TCGA). Methods The transcriptome and pathological data of LUAD patients were downloaded from TCGA. The differentially expressed genes were screened using "edgeR" package in R and analyzed by univariate and multivariate Cox regressions. The expression and clinic value of serum miR-548v in 50 patients with LUAD (study group) and 50 healthy individuals (control group) was detected by the quantitative real time polymerase ch