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However, increases in nutrient availability had little effect on the BPA removal by plants. BPA at 10.0 mg L-1 significantly inhibited the growth of M. spicatum. Therefore, C. demersum may be a candidate for phytoremediation due to greater efficiency for BPA removal and tolerance to BPA pollution. Overall, seedlings of submerged macrophytes from in vitro culture showed great potential for use in phytoremediation of BPA in natural waters, especially C. demersum.Although multiple studies have identified skipping breakfast as a risk facto