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The aim of this study was to present an artificial neural network (ANN) model for the accurate estimation of in-hospital mortality and to demonstrate the validity of the model with real data and a comparison with conventional multiple linear regression models. Retrospective clinical study. University hospital. None. Data were collected from the medical records of 88 patients who had undergone coronary artery bypass graft surgery with an extracorporeal cardiopulmonary pump between January 2018 and March 2020. An ANN approach was used to