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RESULTS IHC studies demonstrated the overexpression of BRD4 in NFPA and GHPA. In vitro and in vivo studies showed that treatment with the BRD4 inhibitor ZBC-260 significantly inhibited the proliferation of PA cells. Further mechanistic studies revealed that ZBC-260 could downregulate the expression of c-Myc, Bcl2 and related genes, which are vital factors in pituitary tumorigenesis. CONCLUSION In this study, we determined the overexpression of BRD4 in NFPA and GHPA and assessed the effects of BRD4 inhibitors on PA cells in

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ADHD Symptoms in Adults Many people who suffer from ADHD continue to struggle with symptoms throughout their lives, particularly when they reach adulthood. This can lead to problems at work and in relationships. It could be hard to keep up with routine tasks like paying bills and keeping track of appointments. This can cause problems with your health as you could be unable to attend important medical appointments or ignore medical instructions. 1. Trouble paying attention ADHD symptoms in