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001). After acid attack, the percentage reduction was placebo 1100 ppm F 1100 TMPnano 1100 TMPmicro (p 0.001). The toothpastes containing TMP showed the highest obliteration of dentinal tubules. The addition of TMPmicro to fluoride toothpaste produced a greater reduction in hydraulic conductance when compared with 1100 ppm F toothpaste. The increased capacity of toothpastes containing TMP to reduce hydraulic conductance indicates their potential to reduce symptoms of dentinal hypersensitivity. The increased capacity