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BACKGROUND Evolvulus alsinoides (Linn.) Linn. (Convolvulaceae) is a therapeutic herb alleviating brain patterns associated with three categories of regulatory principles of the body, mind, and behaviour. In the current research, enzyme inhibition and cytotoxic potentials of E. alsinoides (L.) L. leaf extract has been studied validating its potential application. METHODS The plant phenolics in the leaf extracts obtained via cold-maceration with solvents viz. n-hexane, chloroform, ethyl acetate, methanol, and water were quantitatively an