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Sirt1-/- cardiomyocytes showed down-regulation of L-type Ca2+ channel α1c subunit (Cav1.2) and sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a), but up-regulation of Ca2+ /calmodulin-dependent protein kinase II and NCX. In conclusions, these findings suggest that deficiency of Sirt1 impairs the regulation of intracellular Ca2+ and Na+ in cardiomyocytes, thereby provoking cardiac dysfunction and arrhythmogenesis. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular M

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52 and 5.90 for PD on-state. This study shows that assessment of voice can be used for day to day remote monitoring of PD patients.Bell's palsy impairs the symmetry of facial appearance and movement. Detailed examination of facial muscle activities should be important for the diagnosis and treatment of the Bell's palsy. In this study, facial muscle activities in normal and Bell's palsy conditions were measured using a high-density (HD) electromyography (EMG) technique. The EMG signals during active tasks (four different facial expressio