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4 mL (95% confidence interval [CI] 22,316.6-25,254.1). Thigh volumes decreased significantly in lipoedema and control patients (baseline vs. 1st follow-up, 0.0001 and = 0.0001; baseline vs. 2nd follow-up, 0.0001 and = 0.0013). Adjusted thigh volume reduction amounted to 33.4 and 37.0% in the lipoedema and control groups at the 1st follow-up, and 30.4 and 34.7% at the 2nd follow-up, respectively (lipoedema vs. control 0.999 for both). SG and RYGB led to an equal reduction in leg volume (operation type × time, = 0.83). Volu
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