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Demographic and clinical variables significantly predicted scores on all ANA domains. This study provides an independent test of the recently proposed neuroscience-based ANA framework. Results largely support the novel approach in identifying four core constructs in problem drinkers. Future studies can deepen our understanding of how these domains are relevant to AUD by incorporating biomarkers. This study provides an independent test of the recently proposed neuroscience-based ANA framework. Results largely support the novel approach in