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In silico functional analysis suggested that the CNC8SIG-associated mRNAs are enriched in known cancer-related biological pathways such as the Wnt signaling pathway, the Ras signaling pathway, Rap1 signaling pathway, and PI3K-Akt signaling pathway.Microvessel hypoperfusion following ischemic stress resulted in a decreased shear stress of brain microvascular endothelial cells (BMECs) and contributed to abnormal expression of PECAM-1 after global cerebral ischemia/reperfusion (I/R) injury. Here, we identified novel pathophysiologic and re

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We believe that TTD and multifocality are tumor features that should be considered in future guidelines. Tachyarrhythmia due to atrial fibrillation (AF) is often associated with reduced left ventricular (LV) function and has been proposed to cause arrhythmia-induced cardiomyopathy (AIC). However, the precise diagnostics of AIC and reversibility after rhythm restoration are poorly understood. Our aim was to investigate systolic LV function in tachycardic AF and to evaluate the direct effect of rhythm restoration.