https://vegfr-signal.com/index.....php/cryptococcal-re
Overall, 1057 MSI-H tumors were identified through the 32 932 tested. MSI was examined by NGS making use of 7000+ target microsatellite loci. TMB was calculated only using nonsynonymous missense mutations sequenced with a 592-gene panel; a subset of MSI-H tumors additionally had MMR IHC performed. Analyses examined TMB by MMR necessary protein heterodimer impacted (loss of MLH1/PMS2 vs. MSH2/MSH6 expression) and gene-specific mutations. The test ended up being 54.6% fe
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