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A quantitative measure for such a measurement-induced neural uncertainty can be defined, as this study shows, in terms of the Fisher information, relating the lower bound of this uncertainty to the loss of the Shannon information capacity of neural states.Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive disease with poor prognosis, yet studies have largely been more qualitatively focused. Our study aims to quantitatively predict the risk of occult contralateral lymph node metastasis (cLNM) for HSCC patients with ipsilatera