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Rheumatoid arthritis (RA) is a chronic and refractory autoimmune disease characterized by synovial inflammation with unknown aetiology. Immune system dysfunction mediated by CD4 Tlymphocytes, which is regulated by the cytokine osteopontin (OPN), plays an important role in the pathogenesis of RA. In this study, the levels of peripheral CD4 Tsubsets and serum OPN in patients with active RA were measured and analysed to determine the possible pathogenesis of RA and to provide potential therapeutic targets. Serum OPN levels in both patients