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PubMed, EMBASE, Web of Science, and PsycINFO were looked systematically from September seventeenth, 2021, up to August 11th, 2022. Methodological and conceptual high quality of this included studies had been examined with two appraisal resources. 30 out of 70 suitable articles had been included. mHDGECs experienced lower (HR)QoL compared to pHDGECs and controls, whereas combined results had been reported when comparing to various other neurologic diseases. A f