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pen fractures of extremities is associated with the fracture severity (Gustilo classification). For open fractures of Gustilo types I and II, the final internal fixation should be placed as soon as possible when the recovery of general and local conditions is good and the infection is controlled. Accumulating evidence shows that N6-methyladenine (m A) modulators contribute to the etiology and progression of colorectal cancer (CRC). However, the exact mechanisms of m A reader involved in glycolytic metabolism remain vague. T